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RSS FeedsViruses, Vol. 11, Pages 66: Expanding Repertoire of Plant Positive-Strand RNA Virus Proteases (Viruses)


18 january 2019 10:02:03

Viruses, Vol. 11, Pages 66: Expanding Repertoire of Plant Positive-Strand RNA Virus Proteases (Viruses)

Many plant viruses express their proteins through a polyprotein strategy, requiring the acquisition of protease domains to regulate the release of functional mature proteins and/or intermediate polyproteins. Positive-strand RNA viruses constitute the vast majority of plant viruses and they are diverse in their genomic organization and protein expression strategies. Until recently, proteases encoded by positive-strand RNA viruses were described as belonging to two categories: (1) chymotrypsin-like cysteine and serine proteases and (2) papain-like cysteine protease. However, the functional characterization of plant virus cysteine and serine proteases has highlighted their diversity in terms of biological activities, cleavage site specificities, regulatory mechanisms, and three-dimensional structures. The recent discovery of a plant picorna-like virus glutamic protease with possible structural similarities with fungal and bacterial glutamic proteases also revealed new unexpected sources of protease domains. We discuss the variety of plant positive-strand RNA virus protease domains. We also highlight possible evolution scenarios of these viral proteases, including evidence for the exchange of protease domains amongst unrelated viruses. Digg Facebook Google StumbleUpon Twitter
47 viewsCategory: Epidemiology, Virology
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