Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison (Molecular Cell)

A topoisomerase inhibitor microcin B17 of Escherichia coli is synthesized from a ribosomally made precursor by conversion of serine and cysteine residues to thiazole and oxazole rings. Ghilarov et al. solved the crystal structure of octameric cyclodehydratase/dehydrogenase complex McbBCD, reconciling data from almost 30 years of studies.