Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1 (Structure)

The function of protein phosphatase 1 (PP1) is determined by associated regulatory proteins. Heroes et al. describe the structure of the PP1 regulator SDS22, which largely consists of leucine-rich repeats. They also present a biochemically validated model of the PP1:SDS22 complex and use it as a guide for functional studies.