In this paper, we present an Android application to control and monitor the physiological sensors from the Shimmer platform and its synchronized working with a driving simulator. The Android app can monitor drivers and their parameters can be used to analyze the relation between their physiological states and driving performance. The app can configure, select, receive, process, represent graphically, and store the signals from electrocardiogram (ECG), electromyogram (EMG) and galvanic skin response (GSR) modules and accelerometers, a magnetometer and a gyroscope. The Android app is synchronized in two steps with a driving simulator that we previously developed using the Unity game engine to analyze driving security and efficiency. The Android app was tested with different sensors working simultaneously at various sampling rates and in different Android devices. We also tested the synchronized working of the driving simulator and the Android app with 25 people and analyzed the relation between data from the ECG, EMG, GSR, and gyroscope sensors and from the simulator. Among others, some significant correlations between a gyroscope-based feature calculated by the Android app and vehicle data and particular traffic offences were found. The Android app can be applied with minor adaptations to other different users such as patients with chronic diseases or athletes.