In this study, a numerical simulation has been conducted in order to evaluate the thermal hydraulic performance of a turbulent single-phase flow inside an enhanced tube equipped with a square-cut twisted tape (STT) insert. The classical twisted tape (CTT) insert was also investigated for comparison. The k-ε renormalized group turbulence model has been utilized as the turbulent model. Various twist ratios (y/W) of 2.7, 4.5, and 6.5 were investigated for the Reynolds number range of 8000–18,000, with water as the working fluid. The numerical results indicated that, in comparison with the plain tube (PT), the tube equipped with the STT with the twist ratios of 2.7, 4.5, and 6.5 led to an increase in the values of the Nusselt number and friction factor in the inner tube by 45.4–80.7% and 2.0–3.3 times, respectively; in addition, the highest thermal performance of 1.23 has been obtained. The results further indicated that the tube equipped with the CTT of the same twist ratios improved the Nusselt number and friction factor in the inner tube by 40.3–74.4% and 1.7–3.0 times, respectively, in comparison with the PT; further, the maximum thermal performance of 1.18 was achieved.