A (an) cyclonic (anticyclonic) eddy is usually associated with a cold (warm) core caused by the eddy-induced divergence (convergence) motion. However, there are also some cyclonic (anticyclonic) eddies with warm (cold) cores in the North Pacific, named cyclonic warm-core eddies (CWEs) and anticyclonic cold-core eddies (ACEs) in this study, respectively. Their spatio-temporal characteristics and regional dependence are analyzed using the multi-satellite merged remote sensing datasets. The CWEs are mainly concentrated in the northwestern and southeastern North Pacific. However, besides these two areas, the ACEs are also concentrated in the northeastern Pacific. The annual mean number decreases year by year for both CWEs and ACEs, and the decreasing rate of the CWEs is about two times as large as that of the ACEs. Moreover, the CWEs and ACEs also exhibit a significant seasonal variation, which are intense in summer and weak in winter. Based on the statistics of dynamic characteristics in seven subregions, the Kuroshio Extension region could be considered as the most active area for the CWEs and ACEs. Two possible mechanisms for CW-ACEs generation are discussed by analyzing two cases.