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RSS FeedsIJMS, Vol. 20, Pages 448: Facets of Theiler`s Murine Encephalomyelitis Virus-Induced Diseases: An Update (International Journal of Molecular Sciences)

 
 

22 january 2019 21:01:17

 
IJMS, Vol. 20, Pages 448: Facets of Theiler`s Murine Encephalomyelitis Virus-Induced Diseases: An Update (International Journal of Molecular Sciences)
 


Theiler’s murine encephalomyelitis virus (TMEV), a naturally occurring, enteric pathogen of mice is a Cardiovirus of the Picornaviridae family. Low neurovirulent TMEV strains such as BeAn cause a severe demyelinating disease in susceptible SJL mice following intracerebral infection. Furthermore, TMEV infections of C57BL/6 mice cause acute polioencephalitis initiating a process of epileptogenesis that results in spontaneous recurrent epileptic seizures in approximately 50% of affected mice. Moreover, C3H mice develop cardiac lesions after an intraperitoneal high-dose application of TMEV. Consequently, TMEV-induced diseases are widely used as animal models for multiple sclerosis, epilepsy, and myocarditis. The present review summarizes morphological lesions and pathogenic mechanisms triggered by TMEV with a special focus on the development of hippocampal degeneration and seizures in C57BL/6 mice as well as demyelination in the spinal cord in SJL mice. Furthermore, a detailed description of innate and adaptive immune responses is given. TMEV studies provide novel insights into the complexity of organ- and mouse strain-specific immunopathology and help to identify factors critical for virus persistence.


 
54 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
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