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RSS FeedsAnti-prion systems in yeast [Cell Biology] (Journal of Biological Chemistry)

 
 

2 february 2019 02:01:28

 
Anti-prion systems in yeast [Cell Biology] (Journal of Biological Chemistry)
 




Yeast prions have become important models for the study of the basic mechanisms underlying human amyloid diseases. Yeast prions are pathogenic (unlike the [Het-s] prion of Podospora anserina), and most are amyloid-based with the same in-register parallel ?-sheet architecture as most of the disease-causing human amyloids studied. Normal yeast cells eliminate the large majority of prion variants arising, and several anti-prion/anti-amyloid systems that eliminate them have been identified. It is likely that mammalian cells also have anti-amyloid systems, which may be useful in the same way humoral, cellular, and innate immune systems are used to treat or prevent bacterial and viral infections.


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14 viewsCategory: Biochemistry
 
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