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RSS FeedsAnti-prion systems in yeast [Cell Biology] (Journal of Biological Chemistry)


2 february 2019 02:01:28

Anti-prion systems in yeast [Cell Biology] (Journal of Biological Chemistry)

Yeast prions have become important models for the study of the basic mechanisms underlying human amyloid diseases. Yeast prions are pathogenic (unlike the [Het-s] prion of Podospora anserina), and most are amyloid-based with the same in-register parallel ?-sheet architecture as most of the disease-causing human amyloids studied. Normal yeast cells eliminate the large majority of prion variants arising, and several anti-prion/anti-amyloid systems that eliminate them have been identified. It is likely that mammalian cells also have anti-amyloid systems, which may be useful in the same way humoral, cellular, and innate immune systems are used to treat or prevent bacterial and viral infections. Digg Facebook Google StumbleUpon Twitter
20 viewsCategory: Biochemistry
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