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RSS FeedsIJMS, Vol. 20, Pages 812: Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase (International Journal of Molecular Sciences)

 
 

14 february 2019 17:00:02

 
IJMS, Vol. 20, Pages 812: Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase (International Journal of Molecular Sciences)
 


Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been proposed, in association with diet, to regulate the intestinal peripheral clock. However, the effect of gut dysbiosis on liver remains elusive, despite that germfree mice show alterations in liver metabolic functions and the hepatic daily rhythm. We analyzed whether the disruption of gut microbial populations with various antibiotics would differentially impact liver functions in mice. Our results support the notion of an impact on the hepatic biological rhythm by gram-positive bacteria. In addition, we provide evidence for differential roles of gut microbiota spectra in xenobiotic metabolism that could protect against the harmful pharmacological effects of drugs. Our results underscore a possible link between liver cell proliferation and gram-positive bacteria.


 
31 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 813: The Circadian tau Mutation in Casein Kinase 1 Is Part of a Larger Domain That Can Be Mutated to Shorten Circadian Period (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 811: Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain (International Journal of Molecular Sciences)
 
 
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