Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1 (Structure)

Structure-based prediction or design of protein-protein interactions typically evaluates atomistic models using a physical or statistical energy function. Frappier et al. demonstrate an alternative approach in which the sequence statistics of conserved tertiary structural motifs are used to predict and design peptide interactions with Bcl-2 proteins that control apoptosis.