Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan (Current Biology)

Xie et al. report that eukaryotic elongation factor 2 kinase (eEF2K), which impairs the rate of elongation, decreases misreading or termination readthrough errors and promotes the correct recognition of start codons in mRNAs. Depletion of the eEF2K ortholog or other factors implicated in translation fidelity in C. elegans decreases lifespan.