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RSS FeedsDiverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP (Cell Chemical Biology)

 
 

15 february 2019 12:00:12

 
Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP (Cell Chemical Biology)
 




Demyelinating diseases are characterized by oligodendrocyte loss. A small-molecule screen uncovered novel enhancers of oligodendrocyte formation. Most hits inhibit a narrow range of enzymes in the cholesterol biosynthesis pathway. Structure-activity relationship studies identified CW3388, a potent EBP inhibitor poised for optimization as a remyelinating therapeutic.


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22 viewsCategory: Biology, Chemistry, Biochemistry
 
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