Biochemistry
 |
|
15 february 2019 12:00:12 |
| Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP (Cell Chemical Biology) |
|
Tweet Demyelinating diseases are characterized by oligodendrocyte loss. A small-molecule screen uncovered novel enhancers of oligodendrocyte formation. Most hits inhibit a narrow range of enzymes in the cholesterol biosynthesis pathway. Structure-activity relationship studies identified CW3388, a potent EBP inhibitor poised for optimization as a remyelinating therapeutic. |
| 92 viewsCategory: Biology, Chemistry, Biochemistry |
 Detection of Low-Abundance Metabolites in Live Cells Using an RNA Integrator (Cell Chemical Biology)Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum (Cell Chemical Biology) 
|
| blog comments powered by Disqus |
MyJournals.org
The latest issues of all your favorite science journals on one page
The latest issues of all your favorite science journals on one page
