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RSS FeedsARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer (Cancer Cell)

 
 

15 february 2019 17:00:19

 
ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer (Cancer Cell)
 


Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.


 
77 viewsCategory: Cell Biology, Oncology
 
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