Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells (Neuron)

Zhang et al. uncover the mystery of sub-quanta and quanta during vesicular release of multi-neurotransmitters. Catecholamine sub-quanta are jointly produced by fusion pores and the vesicular matrix, whereas the co-released ATP quanta are fully released during transient fusion events.