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RSS FeedsHuman Fetal TNF-?-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life (Immunity)

 
 

16 february 2019 19:00:08

 
Human Fetal TNF-?-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life (Immunity)
 


The fetal immune system is considered anti-inflammatory; nonetheless, preterm infants are at risk for necrotizing enterocolitis (NEC), a severe intestinal inflammatory disease. Schreurs et al. demonstrate that fetal TNF-?+CD4+ T cells promote gut development early in life. However, in preterm babies these TNF?+CD4+ T cells can mediate intestinal inflammation, providing a potential mechanism for NEC.


 
103 viewsCategory: Immunology
 
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