YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo (Developmental Cell)

As highly differentiated cells, cardiomyocytes have poor renewal capacity, a contributing factor to heart failure in aging and disease. Monroe et al. created a mouse conditionally overexpressing active YAP (YAP5SA) and show that YAP5SA expression induces adult cardiomyocytes to adopt a more proliferative state with fetal-like chromatin and transcriptional landscapes.