Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations (Molecular Cell)

Cells contain millions of proteasomes to degrade abnormal proteins to maintain homeostasis. Understanding the degradation mechanism will benefit therapeutic intervention. Ding et al. report a series of proteasome structures representing the functional cycle of proteasome in action and put forward a mechanistic model of proteasome degradation induced by tetraUb.