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RSS FeedsMicroscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms (Molecular Cell)

 
 

19 february 2019 17:01:49

 
Microscopy-Based Chromosome Conformation Capture Enables Simultaneous Visualization of Genome Organization and Transcription in Intact Organisms (Molecular Cell)
 


Cardozo Gizzi et al. developed Hi-M, a multiplexed imaging-based approach to detect 3D chromatin folding in single cells within intact Drosophila embryos. The ability of Hi-M to detect the spatial organization of cells enabled measurement of changes in TAD organization during early embryogenesis and upon transcriptional activation.


 
72 viewsCategory: Molecular Biology, Cell Biology
 
Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor (Molecular Cell)
Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function (Nature Reviews Molecular Cell Biology)
 
 
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