Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations (Cell Host & Microbe)

In recent years, there has been a great interest in understanding how repeated exposures to influenza can change the already established host antibody repertoire. Lee et al. quantitatively demonstrate that over multiple years and repeated vaccinations, the serum response to influenza is dominated by a small number of persistent antibodies.