Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals (Cell Host & Microbe)

Influenza virus vaccination elicits poor efficacy in elderly individuals. Henry et al. find that elderly adults have a reduced accumulation of de novo immunoglobulin gene somatic mutations and are unable to adapt their antibody responses upon influenza virus vaccination. These results should be considered when designing vaccines for elderly populations.