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RSS FeedsIJMS, Vol. 20, Pages 908: Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson`s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia (International Journal of Molecular Sciences)

 
 

20 february 2019 08:02:59

 
IJMS, Vol. 20, Pages 908: Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson`s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia (International Journal of Molecular Sciences)
 


Mutations of coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10 (CHCHD10) have been found to be linked to Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and/or frontotemporal lobe dementia (FTD). CHCHD2 and CHCHD10 proteins, which are homologous proteins with 54% identity in amino acid sequence, belong to the mitochondrial coiled-coil-helix-coiled-coil-helix (CHCH) domain protein family. A series of studies reveals that these twin proteins form a multimodal complex, producing a variety of pathophysiology by the disease-causing variants of these proteins. In this review, we summarize the present knowledge about the physiological and pathological roles of twin proteins, CHCHD2 and CHCHD10, in neurodegenerative diseases.


 
49 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
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