Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors (Cell Reports)

Cell behavior reflects both the intrinsic state of the cell and extrinsic signals it receives from its microenvironment. By integrating genomic, gene expression, and cell biology datasets from a large number of human iPSCs from healthy donors, Vigilante et al. show how genetic variation contributes to phenotypic variation.