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RSS FeedsNR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair (Cell Reports)

 
 

20 february 2019 08:03:18

 
NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair (Cell Reports)
 


DNA damage induces poly-ADP-ribosylation (PARylation) of repair factors recruited to DNA lesions. Munnur et al. identify a zinc-finger-type poly-ADP-ribose-binding domain in NR4A nuclear orphan receptors that targets PARylated DNA-PKcs repair kinase, facilitating its autophosphorylation and repair of double-strand DNA breaks.


 
49 viewsCategory: Cell Biology
 
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