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20 february 2019 08:03:18

 
ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLC?3 Catalysis: Targeting It Eradicates Leukemia Stem Cells (Cell Reports)
 




Zhong et al. report that abnormal expression of ORP4L is essential for leukemia stem cell survival; it enables IP3 generation by extracting and presenting PIP2 from the plasma membrane to PLC?3 for hydrolysis. The compound LYZ-81, which blocks this process via targeting ORP4L, selectively eradicates leukemia stem cells.


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24 viewsCategory: Cell Biology
 
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