Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing (Cell Reports)

Pachis et al. show that proper binding dynamics of the spindle checkpoint kinase MPS1 to kinetochores are ensured by regulated intramolecular interactions. Perturbing these interactions can lead to inefficient displacement of MPS1 upon microtubule attachment and defects in inactivating the spindle assembly checkpoint, which is necessary for timely chromosome segregation.