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21 february 2019 18:01:57

 
Tulp3 Is a Ciliary Trafficking Gene that Regulates Polycystic Kidney Disease (Current Biology)
 


Legué and Liem show that the cilia gene Tulp3 prevents kidney cystogenesis in development and homeostasis by controlling ciliary protein transport. Loss of Tulp3 in a Pkd1 model of ADPKD ameliorates cystogenesis. Therefore, Tulp3 and its cargoes regulate a cilia-dependent cyst activation signal active in ADPKD.


 
52 viewsCategory: Biology
 
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