Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia (Cancer Cell)

Using a CRISPR/Cas9 screen targeting RNA-binding domains of classical RNA-binding proteins (RBPs), Wang et al. uncover a network of interacting RBPs upregulated in acute myeloid leukemia (AML) and crucial for RNA splicing and AML survival, highlighting RBM39 as a central, targetable component of the RBP network.