System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection (Molecular Cell)

Garcia-Moreno, Noerenberg, Ni, and colleagues developed `comparative RNA-interactome capture` to analyze the RNA-bound proteome during virus infection. More than 200 cellular RNA-binding proteins change their binding activity in response to this challenge, mainly driven by transcript availability. Many of these RNA-binding proteins regulate viral replication and can be targeted to influence infection outcome.