Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum (Cell Chemical Biology)

Gamayun et al. discovered that eeyarestatins (ESs) interfere with closing mechanisms of Sec61 complexes of the ER and, as a `foot in the door,` stabilize Sec61 complexes in a Ca2+-permeable, open state. Specifically, ES24 enhances strongly the Sec61-mediated Ca2+ leakage from ER and induces Ca2+-dependent cell death.