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21 february 2019 20:04:04

 
Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum (Cell Chemical Biology)
 




Gamayun et al. discovered that eeyarestatins (ESs) interfere with closing mechanisms of Sec61 complexes of the ER and, as a `foot in the door,` stabilize Sec61 complexes in a Ca2+-permeable, open state. Specifically, ES24 enhances strongly the Sec61-mediated Ca2+ leakage from ER and induces Ca2+-dependent cell death.


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32 viewsCategory: Biology, Chemistry, Biochemistry
 
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