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RSS FeedsImidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model (Cell Chemical Biology)

 
 

21 february 2019 20:04:04

 
Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model (Cell Chemical Biology)
 




Zhang et al. identified imidazole ketone erastin (IKE) as a potent and metabolically stable inhibitor of system xc- and inducer of ferroptosis. The authors show that IKE exerts an antitumor effect in a mouse xenograft model and exhibits distinct lipid metabolism effects in vitro and in vivo.


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39 viewsCategory: Biology, Chemistry, Biochemistry
 
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