Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes (Cell Metabolism)

Pancreatic beta cells are usually thought as passive victims of immune cell attack in type 1 diabetes (T1D). Thompson et al. now demonstrate that a subpopulation of beta cells becomes senescent and actively promotes the immune-mediated destruction process. Clearance of senescent beta cells with small-molecule inhibitors prevents T1D.