`Lincing` the Y Chromosome to Prostate Cancer: TTTY15 Takes Center Stage (European Urology)

The role of the Y chromosome in cancer biology has been the subject of numerous musings over the decades. Since only half of the population harbors a Y chromosome, and that half only has a single chromosomal copy, modulation of the Y chromosome in genetic males with cancer should be comparatively easy, as fewer genomic events would result in alteration of function compared to other chromosomes. Prostate cancer, with its androgen-driven biology in a male-specific organ, would seem to be a logical disease for Y chromosome modulation.