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RSS FeedsIJMS, Vol. 20, Pages 957: Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology (International Journal of Molecular Sciences)

 
 

22 february 2019 10:00:36

 
IJMS, Vol. 20, Pages 957: Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology (International Journal of Molecular Sciences)
 


Substantial improvements in cancer treatment have resulted in longer survival and increased quality of life in cancer survivors with minimized long-term toxicity. However, infertility and gonadal dysfunction continue to be recognized as adverse effects of anticancer therapy. In particular, alkylating agents and irradiation induce testicular damage that results in prolonged azoospermia. Although damage to and recovery of spermatogenesis after cancer treatment have been extensively studied, there is little information regarding the role of differences in testicular immunology in cancer treatment-induced male infertility. In this review, we briefly summarize available rodent and human data on immunological differences in chemotherapy or radiotherapy.


 
50 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
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IJMS, Vol. 20, Pages 955: The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells (International Journal of Molecular Sciences)
 
 
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