Combined Next-generation Sequencing and Flow Cytometry Analysis for an Anti-PD-L1 Partial Responder over Time: An Exploration of Mechanisms of PD-L1 Activity and Resistance in Bladder Cancer (European Urology Oncology)
As urothelial carcinoma becomes resistant to PD-L1 blockade, additional immune checkpoints may be upregulated, leading to anti-PD-L1 resistance. These data support the concept of combined checkpoint blockade for urothelial carcinoma.