Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues (Cell Reports)

Geng et al. identify FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise, conferring its metabolic benefits on systemic glucose and lipid metabolism and insulin sensitivity. Exercise sensitizes FGF21 actions in adipose tissues, which in turns sends humoral signals to coordinate multi-organ crosstalk for maintaining metabolic homeostasis.