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RSS FeedsSurface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics (Structure)

 
 

14 march 2019 17:04:48

 
Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics (Structure)
 


Li et al. show how cardiolipin acts as both a substrate and a dynamic regulator of cytochrome c`s pro-apoptotic lipid peroxidase functionality. Combining solid-state NMR and mass spectrometry lipidomics, they find that localized motion of the 70-85 ? loop regulates heme cavity access in the peroxidase-active peripherally membrane-bound protein.


 
80 viewsCategory: Biochemistry
 
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