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RSS FeedsHelix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa (Structure)

 
 

14 march 2019 17:04:48

 
Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa (Structure)
 




The Pseudomonas aeruginosa RetS/GacS interaction typifies noncanonical interactions between histidine kinases. Mancl et al. solved the crystal structure of the RetS kinase region and characterized a nontraditional helix-cracking mechanism. In vivo analysis highlights the importance of this mechanism in mediating RetS/GacS interactions, potentially in response to transmembrane signal sensing.


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35 viewsCategory: Biochemistry
 
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