MyJournals Home  

RSS FeedsRad54 phosphorylation promotes homologous recombination by balancing Rad54 mobility and DNA binding. (Biophysical Journal)

 
 

19 march 2019 12:03:36

 
Rad54 phosphorylation promotes homologous recombination by balancing Rad54 mobility and DNA binding. (Biophysical Journal)
 


The repair of DNA double-strand breaks (DSB) by homologous recombination (HR) is of crucial importance for maintaining genomic stability. Two major players during this repair pathway are Rad51 and Rad54. Previously it was shown that Rad54 exists as a monomer or a oligomeric form when bound to DNA and drives the displacement of Rad51 by translocating along the DNA. Moreover, phosphorylation of Rad54 was reported to stimulate this clearance of Rad51 from DNA. However, it is currently unclear how phosphorylation of Rad54 modulates its molecular-structural function and how it affects the activity of monomeric or oligomeric Rad54 during the removal of Rad51.


 
85 viewsCategory: Biophysics
 
Site-specific peptide probes detect buried water in a lipid membrane (Biophysical Journal)
Structural Basis for G Protein–Coupled Receptor Signaling (Annual Review of Biophysics)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Biophysics


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten