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RSS FeedsWidespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice (Cell Reports)

 
 

20 march 2019 02:01:44

 
Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice (Cell Reports)
 


Silencing of Fmr1, the gene that encodes FMRP, causes fragile X syndrome. Das Sharma et al. used ribosome profiling in the cortex of 24-day-old Fmr1 knockout mice to dissect FMRP-mediated translational regulation. Fmr1 loss leads to a relief of translational pausing across a large number of genes.


 
26 viewsCategory: Cell Biology
 
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