Dissecting Cell Lineage Specification and Sex Fate Determination in Gonadal Somatic Cells Using Single-Cell Transcriptomics (Cell Reports)

Using single-cell RNA sequencing of Nr5a1-expressing gonadal somatic cells during female and male sex determination, Stévant et al. deconvoluted the cell lineage specification process and sex-specific differentiation of both the supporting and the steroidogenic cell lineages at a transcriptomic level.