Modeling Patient-Derived Glioblastoma with Cerebral Organoids (Cell Reports)

To address limitations with current preclinical glioblastoma (GBM) models, Linkous et al. establish a `GLICO` (cerebral organoid glioma) model to retro-engineer patient-specific GBMs using patient-derived glioma stem cells and human cerebral organoids. Resulting tumors closely phenocopy patient GBMs and are supported by tumor microtubes that promote invasion into host tissue.