Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology (Cell Stem Cell)

Huttner and colleagues show that an increase in the number of neural progenitor cell processes underlies the proliferative capacity of this population. Expression of human membrane-bound PALMDELPHIN increases the number of progenitor processes and activates integrin signaling, leading to enhanced progenitor proliferation and an increase in upper-layer neurons.