Structures of the PKA RI? Holoenzyme with the FLHCC Driver J-PKAc? or Wild-Type PKAc? (Structure)

Fibrolamellar hepatocellular carcinoma is driven by J-PKAc?, a kinase fusion chimera of the J domain of DnaJB1 with PKAc?, the catalytic subunit of PKA. Here we report the crystal structures of the chimeric RI?2:J-PKAc?2 holoenzyme formed by J-PKAc? and the PKA regulatory (R) subunit RI?, and the wild-type RI?2:PKAc?2 holoenzyme.