Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase (Structure)

Lin et al. determined the crystal structures of active Rab35 in complex with its specific effectors ACAP2 and RUSC2, respectively. The atomic structures not only elucidate the molecular basis of Rab35-effector interactions, but also enable the design of specific Rab35 mutants capable of abolishing Rab35/ACAP2 and Rab35/RUSC2 interactions.