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RSS FeedsAAA+ protein-based technologies to counter neurodegenerative disease (Biophysical Journal)

 
 

22 march 2019 13:03:14

 
AAA+ protein-based technologies to counter neurodegenerative disease (Biophysical Journal)
 




Protein misfolding and overloaded proteostasis networks underlie a range of neurodegenerative diseases. No cures exist for these diseases, but developing effective therapeutic agents targeting the toxic, misfolded protein species in disease is one promising strategy. AAA+ (ATPases Associated with diverse cellular Activities) protein translocases, which naturally unfold and translocate substrate proteins, could be potent therapeutic agents to disassemble toxic protein conformers in neurodegenerative disease.


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28 viewsCategory: Biophysics
 
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