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RSS FeedsIJMS, Vol. 20, Pages 1461: Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review (International Journal of Molecular Sciences)

 
 

22 march 2019 19:03:06

 
IJMS, Vol. 20, Pages 1461: Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review (International Journal of Molecular Sciences)
 




Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and limited to the lungs. Despite the increasing research interest in the pathogenesis of IPF, unfavorable survival rates remain associated with this condition. Recently, novel therapeutic agents have been shown to control the progression of IPF. However, these drugs do not improve lung function and have not been tested prospectively in patients with IPF and coexisting lung cancer, which is a common comorbidity of IPF. Optimal management of patients with IPF and lung cancer requires understanding of pathogenic mechanisms and molecular pathways that are common to both diseases. This review article reflects the current state of knowledge regarding the pathogenesis of pulmonary fibrosis and summarizes the pathways that are common to IPF and lung cancer by focusing on the molecular mechanisms.


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17 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 1463: A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 1462: Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice (International Journal of Molecular Sciences)
 
 
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