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11 april 2019 18:01:17

 
ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner (Structure)
 


UBQLN2, part of protein quality control machinery in cells, phase separates under physiological conditions. Dao, Martyniak, et al. show that a subset of ALS-linked mutations in a C-terminal construct of UBQLN2 disrupt phase separation, promote oligomerization, and change the material properties of UBQLN2 droplets in vitro.


 
61 viewsCategory: Biochemistry
 
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