Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress (Cell Stem Cell)

Brack and colleagues identify a muscle reserve stem cell population marked by Mx1-Cre and Pax3 within the Pax7+ satellite cell pool. After radiation, reserve stem cells clonally expand to become the dominant stem cell population for repair and stem cell maintenance. ROS levels across the satellite cell pool endow radiotolerance.