Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis (Cell Host & Microbe)

Herp et al. find that Mucispirillum schaedleri, a low abundant member of the mammalian intestinal microbiota, metabolically competes with Salmonella enterica serovar Typhimurium, thereby interfering with virulence factor expression and subsequent tissue invasion by Salmonella. These data provide a mechanism by which members of the microbiota can antagonize invading pathogens.