MyJournals Home  

RSS FeedsMolecules, Vol. 24, Pages 1569: Copper-Catalyzed Regioselective Synthesis of (E)-?-Fluorovinyl Sulfones (Molecules)


20 april 2019 09:03:34

Molecules, Vol. 24, Pages 1569: Copper-Catalyzed Regioselective Synthesis of (E)-?-Fluorovinyl Sulfones (Molecules)

Organofluorine compounds are finding increasing application in a variety of fields such as pharmaceutical, agrochemical, and material sciences. However, given the scarcity of fluorine-containing natural products, advancement in this area depends almost entirely on the development of new synthetic methodologies. In this article, we present the synthesis of a series of previously undescribed (E)-β-fluorovinyl sulfones via a simple copper-catalyzed addition of hydrogen fluoride to alkynyl sulfone starting materials in varying yields and E/Z selectivities. The hydrogenation of these products was also explored and compared with the hydrogenation of the related Z isomers. These new products may find interesting applications, given the versatility of vinyl sulfones in chemical synthesis and the unique properties of vinyl fluorides in biological settings. Digg Facebook Google StumbleUpon Twitter
39 viewsCategory: Biochemistry, Chemistry, Molecular Biology
Molecules, Vol. 24, Pages 1561: Labdane and Abietane Diterpenoids from Juniperus oblonga and Their Cytotoxic Activity (Molecules)
Molecules, Vol. 24, Pages 1568: Beer Molecules and Its Sensory and Biological Properties: A Review (Molecules)
blog comments powered by Disqus
The latest issues of all your favorite science journals on one page


Register | Retrieve


Molecular Biology

Use these buttons to bookmark us: Digg Facebook Google StumbleUpon Twitter

Valid HTML 4.01 Transitional
Copyright © 2008 - 2019 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn